| Expression pattern: |
UP |
| Associated gene: |
SERPINA3 |
| Associated microRNA: |
- |
| Biological function: |
Circ_0033074 showed the highest magnitude of upregulation in PCA tissues and was suggested as a potential biomarker for PCA diagnosis, treatment and follow-up; no direct functional experiment was performed. |
| Molecular mechanism: |
Bioinformatics-based analysis suggested that the expression trend of circ_0033074 was consistent with the oncogenic function of its host gene SERPINA3; targeted miRNAs were predicted by miRanda, but no specific miRNA or direct mechanism was experimentally validated. |
| Biological pathway or process: |
ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May become a novel biomarker for diagnosis, treatment and follow-up in PCA, but this was not clinically validated. |
| Description: |
Circ_0033074 was identified by microarray as the most strongly upregulated circRNA in PCA tissues compared with matched non-cancerous tissues. The study linked it bioinformatically to its host gene SERPINA3 and suggested that differentially expressed circRNAs may serve as future PCA biomarkers, but no RT-qPCR or functional validation was performed. |
| Confidence score: |
0.348 |