| Expression pattern: |
UP |
| Associated gene: |
IGFBP2 |
| Associated microRNA: |
miR-1184 |
| Biological function: |
promotes bladder cancer cell proliferation, migration, invasion and tumorigenesis |
| Molecular mechanism: |
ceRNA (miRNA sponge): circVANGL1 sponges miR-1184 to increase IGFBP2 expression |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes); PI3K/AKT/mTOR (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; FISH / smFISH; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation |
| Clinical significance: |
circVANGL1 might be a promising prognostic biomarker for BC |
| Description: |
circVANGL1 is up-regulated in bladder cancer tissues and cell lines and predominantly localized in the cytoplasm. It promotes bladder cancer cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-1184 to increase IGFBP2 expression (circVANGL1/miR-1184/IGFBP2 ceRNA axis). |
| Confidence score: |
0.697 |