| Expression pattern: |
UP |
| Associated gene: |
ITGB8 |
| Associated microRNA: |
miR-761 |
| Biological function: |
Circ-TTBK2 promotes glioma cell proliferation, invasion and tumor growth, and suppresses ferroptosis; circ-TTBK2 knockdown retards proliferation and invasion and promotes ferroptosis. |
| Molecular mechanism: |
Circ-TTBK2 functions as a ceRNA/sponge for miR-761, thereby modulating ITGB8 expression through the miR-761/ITGB8 axis. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); ferroptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Flow Cytometry（Non-apoptosis/cycle）; Western Blot; In Vivo Animal Model |
| Clinical significance: |
providing a promising biomarker for the clinical therapy of human glioma |
| Description: |
Circ-TTBK2 is up-regulated in human glioma tissues and glioma cell lines. It promotes glioma proliferation, invasion and xenograft tumor growth while suppressing ferroptosis through a ceRNA mechanism in which circ-TTBK2 sponges miR-761 to upregulate ITGB8. The study proposes circ-TTBK2 as a potential therapeutic biomarker or target for human glioma. |
| Confidence score: |
0.7177 |