circRNA basic information
circBase ID: hsa_circ_0000989
Name: hsa_circ_BIRC6
Synonym: CircBIRC6
Host Gene: BIRC6
Genomic location(hg19): chr2:32602655-32631625:+
Genomic location(hg38): chr2:32377587-32406557:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary tumor; lung; brain; metastatic lesions
Cell lines:

4T1; 4T1T; 4T1B; 4T1L
In vivo animal model:

syngeneic model
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circBIRC6 was upregulated in metastatic breast tumor cells and was proposed to correlate with higher cancer stem cell properties, spheroid formation, stemness, and aggressiveness of metastatic cells.
Molecular mechanism: The study did not experimentally define a molecular mechanism; it proposed that high circBIRC6 expression may be associated with cancer stem cell properties in metastatic breast cancer cells.
Biological pathway or process:

stemness (promotes); metastasis (promotes); proliferation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; In Vivo Animal Model; H&E Staining
Clinical significance:

circBIRC6 was suggested as a marker for the identification of breast cancer stem cells.
Description:

This study found that cicBIRC6/circBIRC6 was significantly upregulated in metastatic breast tumor cells compared with primary tumor cells, with higher expression in brain metastatic 4T1B cells than lung metastatic 4T1L cells. The authors proposed that elevated circBIRC6 is associated with increased spheroid formation, stemness, and aggressiveness of metastatic breast cancer cells, suggesting potential value as a marker of breast cancer stem cells.
Confidence score:

0.3513
Other information
Title:

High percentage of Cancer Stem cells in metastatic locations: Upregulation of cicBIRC6 in highly metastatic breast Cancer Subline.

Journal: Molecular biology reports
Published: 2023
PubMed ID: 36456770
Study type:

biological research
Data availability: All data generated or analyzed during this study are included in this published article; supplementary material available at https://doi.org/10.1007/s11033- 022-08024-6
Code availability: -