circRNA basic information
circBase ID: -
Name: hsa_circ_CSNK1G3
Synonym: circCSNK1G3
Host Gene: CSNK1G3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008315
MONDO name: prostate cancer
Disease details: prostate cancer / PCa
Disease DO ID:
 10283
Disease MeSH ID:
 D011471
Disease NCIt ID:
 C7378
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

prostate tumors; treatment-naive surgical specimen
Cell lines:

LNCaP; V16A; 22Rv1; PC-3; HCT-116; A549; HEK293FT
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: CBX7, CDK1, CDC25A
Associated microRNA: miR-181b, miR-181d
Biological function: promotes prostate cancer cell proliferation and cell-cycle-related gene programs
Molecular mechanism: circCSNK1G3 promotes cell proliferation at least partially through interaction with miR-181b/d and regulation of CBX7 and cell-cycle genes
Biological pathway or process:

proliferation (promotes); cell cycle (promotes); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; RNA-seq; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Transfection; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circCSNK1G3 is a human circRNA derived from CSNK1G3 that is essential for proliferation of prostate cancer cell lines. It mainly localizes in the cytoplasm and promotes cell proliferation at least partly through interaction with miR-181b/d, affecting CBX7 and cell-cycle genes such as CDK1 and CDC25A.
Confidence score:

0.7254
Other information
Title:

Widespread and Functional RNA Circularization in Localized Prostate Cancer.

Journal: Cell
Published: 2019
PubMed ID: 30735634
Study type:

combined biological and clinical study
Data availability: EGA: EGAS00001000900; EGA: EGAS00001002816; GEO: GSE113124; GEO: GSE84043; dbGaP ID: phs000915.v1.p; TCGA
Code availability: -