| Expression pattern: |
UP |
| Associated gene: |
GLUT1 |
| Associated microRNA: |
miR-760 |
| Biological function: |
Accelerates colorectal cancer cell proliferation, migration, glycolysis, and in vivo tumor growth; circDENND4C knockdown suppresses these malignant phenotypes. |
| Molecular mechanism: |
circDENND4C functions as a miR-760 sponge to regulate GLUT1, thereby promoting proliferation, migration and glycolysis of colorectal cancer cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); glycolysis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis; In Vivo Animal Model |
| Clinical significance: |
Potential new diagnostic target and therapeutic strategy reference for colorectal cancer cells. |
| Description: |
circDENND4C is up-regulated in colorectal cancer tissues and cells. It promotes colorectal cancer cell proliferation, migration, glycolysis, and xenograft tumor growth by sponging miR-760 to regulate GLUT1 expression. Knockdown of circDENND4C suppresses these malignant phenotypes, suggesting potential diagnostic or therapeutic relevance. |
| Confidence score: |
0.6521 |