circRNA basic information
circBase ID: hsa_circ_0008717
Name: hsa_circ_ABCB10
Synonym: Circular RNA-ABCB10 / circ-ABCB10
Host Gene: ABCB10
Genomic location(hg19): chr1:229665945-229678118:-
Genomic location(hg38): chr1:229530198-229542371:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: Hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumor tissues; adjacent normal tissues
Cell lines:

97H; 97L; BEL-7402; Hep3B; HepG2; SMMC-7721; SNU423; L-02
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: NRP1, ABL2
Associated microRNA: miR-340-5p, miR-452-5p
Biological function: circ-ABCB10 inhibits HCC cell proliferation, migration, invasion, colony formation and tumor growth, and promotes apoptosis.
Molecular mechanism: circ-ABCB10 acts as a miRNA sponge for miR-340-5p and miR-452-5p, thereby upregulating NRP1 and ABL2 expression through the miR-340-5p/miR-452-5p-NRP1/ABL2 signaling axis.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

circ-ABCB10 expression was positively correlated with histological grade and tumor size, and the study suggests it may be a promising biomarker and therapeutic target for HCC.
Description:

In this study, circ-ABCB10 is downregulated in HCC tissues and cell lines and acts as an anti-oncogenic circRNA. Its overexpression suppresses proliferation, migration, invasion, colony formation and xenograft tumor growth while promoting apoptosis. Mechanistically, circ-ABCB10 sponges miR-340-5p and miR-452-5p to upregulate NRP1 and ABL2, suggesting a potential biomarker and therapeutic target role in HCC.
Confidence score:

0.7052
Other information
Title:

Circular RNA-ABCB10 suppresses hepatocellular carcinoma progression through upregulating NRP1/ABL2 via sponging miR-340-5p/miR-452-5p.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 32196586
Study type:

combined biological and clinical study
Data availability: -
Code availability: -