| Expression pattern: |
DN |
| Associated gene: |
eukaryotic translation elongation factor 2 (eEF2), F-actin, Quaking-5 / QKI-5 |
| Associated microRNA: |
- |
| Biological function: |
hsa_circ_0098181 suppresses HCC metastasis, migration and invasion in vitro and in vivo. |
| Molecular mechanism: |
hsa_circ_0098181 interacts with and sequesters eEF2, dissociates eEF2 from F-actin, prevents F-actin formation, activates the Hippo signaling pathway, and its biogenesis is induced by QKI-5. |
| Biological pathway or process: |
Hippo/YAP (promotes); metastasis (inhibits); migration (inhibits); invasion (inhibits); EMT (inhibits); Wnt/beta-catenin (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Sanger Sequencing; Actinomycin D / DRB Stability Assay; RNase R Treatment; Transfection; Transwell Assay; In Vivo Animal Model; H&E Staining; Western Blot; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); RNA Pull-Down; RIP (RNA Immunoprecipitation); FISH / smFISH; IF (Immunofluorescence); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Low hsa_circ_0098181 expression is associated with unfavorable metastatic features, shorter DFS and OS, and is an independent prognostic factor for DFS and OS. |
| Description: |
hsa_circ_0098181 is down-regulated in HCC and low expression is linked to metastatic features and poor prognosis. Functionally, it suppresses migration, invasion and metastasis by sequestering eEF2, preventing F-actin formation and activating Hippo signaling; QKI-5 promotes its biogenesis. |
| Confidence score: |
0.8668 |