| Expression pattern: |
DN |
| Associated gene: |
E-cadherin, N-cadherin, Vimentin |
| Associated microRNA: |
- |
| Biological function: |
circ-SMAD7 inhibits CRC cell migration and invasion and suppresses the EMT process. |
| Molecular mechanism: |
circ-SMAD7 suppresses CRC migration and invasion by inhibiting the epithelial-to-mesenchymal transition process and regulating EMT-related proteins. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; Wound Healing Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis |
| Clinical significance: |
circ-SMAD7 expression was positively associated with patients' overall survival time, and circ-SMAD7 may serve as a prospective therapeutic target for CRC. |
| Description: |
circ-SMAD7 is downregulated in colorectal cancer tissues and CRC cell lines. Higher circ-SMAD7 expression is associated with better overall survival, and functional assays indicate that circ-SMAD7 suppresses CRC cell migration and invasion by inhibiting EMT and regulating E-cadherin, N-cadherin, and Vimentin. |
| Confidence score: |
0.6527 |