| Expression pattern: |
UP |
| Associated gene: |
TACR1 |
| Associated microRNA: |
miR-940 |
| Biological function: |
promotes cell viability, migration, invasion and colony formation; inhibits apoptosis; promotes cell cycle progression; promotes xenograft tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circ_0091579 sponges miR-940 to regulate TACR1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
- |
| Description: |
hsa_circ_0091579 (circ_0091579) is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation/colony formation, migration/invasion, induces G0/G1 arrest and apoptosis, and reduces xenograft tumor growth by acting as a ceRNA that sponges miR-940 to upregulate TACR1. |
| Confidence score: |
0.7421 |