| Expression pattern: |
UP |
| Associated gene: |
ZNF146 |
| Associated microRNA: |
miR-376c-3p |
| Biological function: |
promotes gastric cancer cell proliferation, migration and invasion; inhibits apoptosis; promotes in vivo tumor growth |
| Molecular mechanism: |
ceRNA mechanism: circPIP5K1A sponges miR-376c-3p to upregulate ZNF146 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; EdU Staining; Transwell Assay; TUNEL; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Clinical Sample Validation |
| Clinical significance: |
high circPIP5K1A expression was associated with big tumor diameter, advanced stage and distant metastasis; high circPIP5K1A level predicted poorer prognosis |
| Description: |
circPIP5K1A is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes GC proliferation, migration/invasion and tumor growth while inhibiting apoptosis, acting as a ceRNA that sponges miR-376c-3p to increase ZNF146 expression; high expression is associated with adverse clinicopathological features and poorer survival. |
| Confidence score: |
0.873 |