circRNA basic information
circBase ID: hsa_circ_0007376
Name: hsa_circ_MAP2K2
Synonym: -
Host Gene: MAP2K2
Genomic location(hg19): chr19:4101016-4101278:-
Genomic location(hg38): chr19:4101018-4101280:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

gastric cancer tissues; plasma
Cell lines:

SGC-7901; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KLK10, CXCR4, CDC42, API5, EYA4, EDNRA, DIO1, SMAD4, PEBP1, TCEAL1, PHLPP1, HOXD10, PTX3, MBD2, TPD52, TRIB1, CDH1, APLN, CASP7, CASP3, MTOR, PHLPP2, RASSF8
Associated microRNA: hsa-miR-571, hsa-miR-224-5p
Biological function: unknown
Molecular mechanism: Predicted circRNA-miRNA-mRNA (ceRNA) network based on bioinformatics
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Bioinformatics Analysis; Transfection
Clinical significance:

The network may become a new molecular biomarker
Description:

hsa_circ_0007376 is up-regulated in gastric cancer tissue and plasma datasets and shows higher expression in SGC-7901 than GES-1 by RT-qPCR. It is included in the predicted circRNA-miRNA-mRNA network as a putative ceRNA, but no specific functional mechanism was experimentally validated.
Confidence score:

0.3684
Other information
Title:

Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis.

Journal: World journal of surgical oncology
Published: 2022
PubMed ID: 35164778
Study type:

combined biological and clinical study
Data availability: GSE83521; GSE93541
Code availability: -