| Expression pattern: |
UP |
| Associated gene: |
Bcl-2, PCNA, ASCT2, GLS1 |
| Associated microRNA: |
miR-598 |
| Biological function: |
circB3GNTL1 promotes proliferation and glutamine decomposition/glutaminolysis of gastric cancer cells and inhibits apoptosis; knockdown of circB3GNTL1 suppresses proliferation and glutamine decomposition and induces apoptosis. |
| Molecular mechanism: |
circB3GNTL1 targets and controls miR-598 expression; miR-598 inhibition partially reverses the effects of circB3GNTL1 knockdown on proliferation, apoptosis and glutamine decomposition. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); glutaminolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; RNase R Treatment; Transfection; MTT; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; Bioinformatics Analysis |
| Clinical significance: |
Potential new goal for clinical diagnosis and treatment of gastric cancer. |
| Description: |
This study reports that circB3GNTL1 is up-regulated in gastric cancer tissues and AGS gastric cancer cells. Functional knockdown experiments indicate that circB3GNTL1 promotes gastric cancer cell proliferation and glutamine decomposition/glutaminolysis while inhibiting apoptosis, at least partly through targeting and regulating miR-598. |
| Confidence score: |
0.7372 |