circRNA basic information
circBase ID: -
Name: hsa_circ_URI1
Synonym: Circ-URI1 / circURI1
Host Gene: URI1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer / GC
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

AGS; MKN-28; HGC-27; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: biomarker for gastric cancer detection/diagnosis and staging
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; ROC Analysis; Bioinformatics Analysis
Clinical significance:

EV-circURI1 (as part of a four-marker EV-circRNA panel) differentiates healthy donors from gastric cancer patients and supports early-stage gastric cancer diagnosis using BEISA combined with machine learning.
Description:

EV-associated circ-URI1 is up-regulated in gastric cancer plasma samples and is used as one of four EV-circRNA biomarkers measured by the BEISA platform. Together with the other markers and machine learning, it supports noninvasive classification of healthy donors vs gastric cancer patients and helps early-stage diagnosis.
Confidence score:

0.5121
Other information
Title:

Bimodal In Situ Analyzer for Circular RNA in Extracellular Vesicles Combined with Machine Learning for Accurate Gastric Cancer Detection.

Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Published: 2025
PubMed ID: 39823497
Study type:

combined biological and clinical study
Data availability: Research data are not shared.
Code availability: -