| Expression pattern: |
DN |
| Associated gene: |
KANK1 |
| Associated microRNA: |
miR-31-5p |
| Biological function: |
Enhances 5-Fu sensitivity, promotes apoptosis, inhibits invasion, EMT, tumor growth, 5-Fu resistance and CRC progression. |
| Molecular mechanism: |
circDDX17 functions as a ceRNA/molecular sponge for miR-31-5p, thereby increasing KANK1 expression and reducing 5-Fu resistance and tumor progression. |
| Biological pathway or process: |
apoptosis (promotes); invasion (inhibits); EMT (inhibits); drug resistance (inhibits); chemoresistance (inhibits); ceRNA regulation (other); proliferation (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
May provide a promising target or effective treatment strategy for CRC patients. |
| Description: |
circDDX17 is down-regulated in colorectal cancer tissues and cells. Its upregulation enhances 5-Fu sensitivity, promotes apoptosis, and suppresses invasion, EMT and tumor growth by sponging miR-31-5p and increasing KANK1 expression. The study suggests circDDX17 may be a therapeutic target for overcoming CRC chemoresistance. |
| Confidence score: |
0.6536 |