| Expression pattern: |
UP |
| Associated gene: |
PDK4 |
| Associated microRNA: |
miR-148a-3p |
| Biological function: |
Promotes NSCLC cell proliferation, migration/metastasis, and aerobic glycolysis; circFTO knockdown suppresses tumor growth and metastasis. |
| Molecular mechanism: |
ceRNA mechanism: circFTO sponges miR-148a-3p to upregulate PDK4, enhancing glycolysis and malignant progression; delivered via M2 macrophage-derived sEV. |
| Biological pathway or process: |
glycolysis (promotes); proliferation (promotes); migration (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; FISH / smFISH; Sanger Sequencing; divergent primers PCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Survival Analysis; Bioinformatics Analysis; circRNA-seq |
| Clinical significance: |
High circFTO expression correlates negatively with NSCLC patient survival; proposed as prognostic and diagnostic biomarker. |
| Description: |
circFTO is upregulated in NSCLC tissues/cell lines and enriched in M2 macrophage-derived sEV. It promotes NSCLC proliferation, migration/metastasis and aerobic glycolysis by sponging miR-148a-3p to upregulate PDK4, and high circFTO predicts poorer overall survival. |
| Confidence score: |
0.8482 |