| Expression pattern: |
DN |
| Associated gene: |
ABCA3 |
| Associated microRNA: |
- |
| Biological function: |
Potential diagnostic biomarker for NSCLC; expression level may negatively correlate with lung cancer development. |
| Molecular mechanism: |
Detailed molecular mechanism unknown; possible relationship with ABCA3 locus/expression was explored but no correlation with ABCA3 expression was found. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
The AUC of hsa_circ_0037516 was 0.82, with a sensitivity of 0.65 and a specificity of 0.84; the two circRNAs combined achieved AUC 0.9, suggesting diagnostic value for NSCLC. |
| Description: |
hsa_circ_0037516 is derived from the ABCA3 locus and is significantly downregulated in NSCLC tissues and lung cancer cell lines. The study supports its potential diagnostic utility for NSCLC, with an individual ROC AUC of 0.82 and improved diagnostic performance when combined with hsa_circ_0037515. |
| Confidence score: |
0.6238 |