| Expression pattern: |
UP |
| Associated gene: |
ONECUT2, AGO2, exportin-2 |
| Associated microRNA: |
hsa-miR-571 |
| Biological function: |
promotes GC cell proliferation and migration; promotes tumorigenesis and metastasis |
| Molecular mechanism: |
ceRNA/miRNA sponge: circRERE(4-5) sponges miR-571 to derepress/upregulate ONECUT2 |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); ROC Analysis; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
plasma circRERE(4-5) levels correlated closely with GC size and metastasis; ROC AUC 0.8611 for distinguishing GC patients from healthy controls; AUC 0.8241 for distinguishing distant metastasis vs non-metastasis |
| Description: |
circRERE(4-5) is up-regulated in gastric cancer tissues/cells and in patient plasma, and higher plasma levels associate with tumor size and distant metastasis. Mechanistically, it acts as a ceRNA by sponging miR-571 to derepress ONECUT2, thereby promoting GC cell proliferation, migration, tumor growth and metastasis; ASO-mediated targeting suppresses xenograft growth and lung colonization. |
| Confidence score: |
0.8912 |