circRNA basic information
circBase ID: hsa_circ_0003423
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr18:56601664-56621031:+
Genomic location(hg38): chr18:58934432-58953799:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

AGS; HGC27
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Predicted to be associated with MAPK-related signaling and endoplasmic reticulum stress responses in berberine-treated gastric cancer cells (enrichment based on putative target genes).
Molecular mechanism: Assumed to act as a miRNA sponge in a predicted circRNA-miRNA-mRNA network.
Biological pathway or process:

MAPK (other); ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0003423 is up-regulated by berberine treatment in gastric cancer cell lines. The study predicts a ceRNA role for hsa_circ_0003423 as a miRNA sponge, with enrichment of its putative target genes pointing to MAPK-family signaling cascades and ER-stress-related responses.
Confidence score:

0.2465
Other information
Title:

Effects of Berberine on Circular RNA Expression Profiles in Human Gastric Cancer Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM
Published: 2021
PubMed ID: 34055022
Study type:

biological research
Data availability: The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -