circRNA basic information
circBase ID: hsa_circ_0101996
Name: hsa_circ_SOS2
Synonym: -
Host Gene: SOS2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0006143
MONDO name: cervical squamous cell carcinoma
Disease details: cervical squamous cell carcinoma / CSCC
Disease DO ID:
 3744
Disease MeSH ID:
 -
Disease NCIt ID:
 C4028
Disease ICD11 ID:
 1544785014
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral whole blood; tumor tissues; paired adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: May serve as a non-invasive diagnostic biomarker for CSCC detection.
Molecular mechanism: Hypothesized involvement in CSCC progression by activation of MAPK signaling based on its SOS2 origin.
Biological pathway or process:

MAPK (other)
Detected method:
Q
M
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RT-qPCR; Microarray; Clinical Sample Validation; ROC Analysis
Clinical significance:

Could distinguish CSCC patients from healthy controls with an AUC of 0.906; combined with hsa_circ_0101119 increased AUC to 0.964.
Description:

hsa_circ_0101996 is significantly up-regulated in peripheral whole blood from CSCC patients and shows diagnostic value for distinguishing CSCC from healthy controls. The study suggests that combining hsa_circ_0101996 with hsa_circ_0101119 improves diagnostic performance, while a MAPK-related mechanism is proposed but not experimentally validated.
Confidence score:

0.5662
Other information
Title:

Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma.

Journal: International journal of clinical and experimental pathology
Published: 2017
PubMed ID: 31966557
Study type:

combined clinical and bioinformatics study
Data availability: GSE102686
Code availability: -