| Expression pattern: |
DN |
| Associated gene: |
PTEN, p21, AGO2 |
| Associated microRNA: |
miR-130a-3p |
| Biological function: |
inhibits proliferation, migration, and invasion; suppresses tumor growth and lung metastasis |
| Molecular mechanism: |
ceRNA mechanism: circGRAMD1B sponges miR-130a-3p to regulate PTEN and p21 expression |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); EMT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; divergent primers PCR; Sanger Sequencing; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
lower circGRAMD1B expression in GC tissues was correlated with tumor size and T stage |
| Description: |
circGRAMD1B (hsa_circ_0004798), derived from GRAMD1B, is down-regulated in gastric cancer and mainly localized in the cytoplasm. It suppresses GC cell proliferation, migration, invasion and in vivo tumor growth/metastasis by acting as a ceRNA that sponges miR-130a-3p, thereby restoring PTEN and p21 expression. |
| Confidence score: |
0.8635 |