circRNA basic information
circBase ID: -
Name: hsa_circ_MTO1
Synonym: circMTO1
Host Gene: MTO1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjacent non-tumor tissues
Cell lines:

SW480; SW620; HT-29; HCT-116; FHC
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: beta-catenin, c-myc, cyclin D1
Associated microRNA: -
Biological function: circMTO1 acts as a tumor suppressor in CRC and suppresses CRC cell proliferation, migration, and invasion; circMTO1 inhibition promotes proliferation, colony formation, migration, invasion, and cell-cycle progression.
Molecular mechanism: circMTO1 suppresses CRC progression by regulating and inactivating the Wnt/beta-catenin signaling pathway; circMTO1 inhibition activates Wnt/beta-catenin signaling and increases beta-catenin, c-myc, and cyclin D1 expression.
Biological pathway or process:

Wnt/beta-catenin (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); cell cycle (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Wound Healing Assay; Transwell Assay; Western Blot; Cohort Study; Survival Analysis
Clinical significance:

Low circMTO1 expression was associated with advanced TNM stage, lymph node metastasis, and poor overall survival; circMTO1 may serve as a potential predictor, biomarker, and therapeutic target for CRC.
Description:

circMTO1 is down-regulated in colorectal cancer tissues and cell lines, and low expression is associated with advanced TNM stage, lymph node metastasis, and poor overall survival. Functionally, circMTO1 suppresses CRC cell proliferation, migration, and invasion, at least partly by inhibiting the Wnt/beta-catenin signaling pathway and its downstream targets beta-catenin, c-myc, and cyclin D1.
Confidence score:

0.6591
Other information
Title:

CircMTO1 inhibits cell proliferation and invasion by regulating Wnt/beta-catenin signaling pathway in colorectal cancer.

Journal: European review for medical and pharmacological sciences
Published: 2018
PubMed ID: 30556859
Study type:

combined biological and clinical study
Data availability: -
Code availability: -