circRNA basic information
circBase ID: hsa_circ_0040823
Name: hsa_circ_BANP
Synonym: circBANP
Host Gene: BANP
Genomic location(hg19): chr16:88061088-88071617:+
Genomic location(hg38): chr16:88027482-88038011:+
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer / BCa
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum specimens
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-516b-5p
Biological function: Potential serum biomarker for prediction of bladder cancer recurrence, especially in combination with circFARSA.
Molecular mechanism: Predicted endogenous miRNA sponge for miR-516b-5p; no functional mechanism was experimentally validated in bladder cancer.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

A combination of circFARSA and circBANP levels discriminated patients with tumor recurrence from those without, with AUC 0.737; the best predictive value was for low grade tumors with AUC 0.839.
Description:

Although circBANP was not significantly different between BC patients and healthy controls, it was up-regulated in recurrent BC compared with non-recurrent patients. The study proposes serum circBANP, especially combined with circFARSA, as a prognostic biomarker for recurrence, with predicted miRNA-sponge activity toward miR-516b-5p.
Confidence score:

0.459
Other information
Title:

Detection of serum long non-coding RNA UCA1 and circular RNAs for the diagnosis of bladder cancer and prediction of recurrence.

Journal: International journal of clinical and experimental pathology
Published: 2019
PubMed ID: 31934131
Study type:

clinical study
Data availability: GEO database
Code availability: -