| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-635 |
| Biological function: |
Potential serum biomarker for bladder cancer diagnosis and recurrence prediction, especially in combination with lncRNA UCA1 for diagnosis. |
| Molecular mechanism: |
Predicted endogenous miRNA sponge for miR-635; no functional mechanism was experimentally validated in bladder cancer. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
The lncRNA UCA1 and circSHKBP1 signature distinguished BC patients from controls with AUC 0.804 and showed more optimal performance for low volume tumors (AUC 0.870); circSHKBP1 was also higher in recurrent BC than non-recurrent patients. |
| Description: |
Serum circSHKBP1 was up-regulated in bladder cancer and recurrent BC. Its combination with lncRNA UCA1 showed diagnostic value for distinguishing BC patients from controls, and circSHKBP1 was predicted to act as an endogenous sponge for miR-635. |
| Confidence score: |
0.459 |