| Expression pattern: |
UP |
| Associated gene: |
AKT3, Ago2 |
| Associated microRNA: |
miR-3680-3p |
| Biological function: |
Upregulation of circ-PRKCI promotes ESCC cell proliferation and migration, while downregulation inhibits cell proliferation and migration. |
| Molecular mechanism: |
circ-PRKCI functions as a ceRNA and molecular sponge for miR-3680-3p to upregulate AKT3 expression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Western Blot; Nuclear-Cytoplasmic Fractionation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
May provide a new perspective on the diagnosis and treatment of ESCC; ROC analysis was performed to detect the relationship between circ-PRKCI and ESCC. |
| Description: |
circ-PRKCI is upregulated in ESCC tissues and promotes ESCC cell proliferation and migration. Mechanistically, it acts as a ceRNA by sponging miR-3680-3p, thereby upregulating AKT3 expression in the circ-PRKCI/miR-3680-3p/AKT3 regulatory network. |
| Confidence score: |
0.8162 |