| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
ciRS-7 promotes viability, proliferation, invasion, migration and EMT of cervical cancer cells, and suppresses apoptosis; high ciRS-7 expression is associated with large tumor size, advanced FIGO stage, deep invasion, metastatic lymph nodes, HPV infection and unfavorable prognosis. |
| Molecular mechanism: |
The study functionally tested ciRS-7 overexpression in cervical cancer cells and reported increased proliferation-related proteins and EMT marker changes; direct miRNA or pathway mechanisms were not experimentally validated. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); EMT (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Cohort Study; Survival Analysis; ROC Analysis |
| Clinical significance: |
ciRS-7 has diagnostic potential for cervical cancer and CIN discrimination, and high ciRS-7 expression is associated with unfavorable prognosis and aggressive clinicopathological features. |
| Description: |
This study found that ciRS-7 is up-regulated in cervical cancer and CIN compared with healthy controls, and is abundantly expressed in cervical cancer tissues versus adjacent non-tumor tissues. High ciRS-7 expression is associated with poor prognosis and aggressive clinical features, and ciRS-7 overexpression promotes cervical cancer cell proliferation, viability, migration, invasion and EMT while inhibiting apoptosis. The study supports ciRS-7 as a potential diagnostic and prognostic biomarker for cervical cancer. |
| Confidence score: |
0.6742 |