| Expression pattern: |
UP |
| Associated gene: |
FAM83F, Bax, Bcl-2, P-gp |
| Associated microRNA: |
miR-512-5p |
| Biological function: |
circ_0010235 promotes paclitaxel resistance, proliferation, angiogenesis, migration and invasion of PTX-resistant NSCLC cells and suppresses apoptosis; circ_0010235 knockdown enhances PTX-induced cytotoxicity and antitumor sensitivity. |
| Molecular mechanism: |
circ_0010235 acts as a ceRNA by sponging miR-512-5p to positively regulate FAM83F expression, thereby stimulating paclitaxel resistance in NSCLC. |
| Biological pathway or process: |
drug resistance (promotes); chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; Nuclear-Cytoplasmic Fractionation; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circ_0010235/miR-512-5p/FAM83F axis may be a potential therapeutic option for patients with NSCLC who are resistant to PTX. |
| Description: |
circ_0010235 is upregulated in NSCLC and especially in PTX-resistant NSCLC tissues and cells. It promotes paclitaxel resistance and malignant phenotypes by sponging miR-512-5p to increase FAM83F expression, while knockdown of circ_0010235 improves PTX sensitivity in vitro and in a xenograft model. |
| Confidence score: |
0.7859 |