| Expression pattern: |
DN |
| Associated gene: |
SIRT1 |
| Associated microRNA: |
miR-3619-5p |
| Biological function: |
Circ_0022383 overexpression attenuated IL-1beta-induced proliferation arrest, apoptosis, inflammation and extracellular matrix degradation in chondrocytes. |
| Molecular mechanism: |
Circ_0022383 acts as a ceRNA by sponging miR-3619-5p to regulate SIRT1 in IL-1beta-induced chondrocytes. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); apoptosis (inhibits); inflammation (inhibits); other pathway/process (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; EdU Staining; ELISA; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
Circ_0022383 was suggested as a valuable marker target for OA prevention. |
| Description: |
Circ_0022383 is down-regulated in OA cartilage and IL-1beta-induced human primary chondrocytes. Its overexpression protects chondrocytes by promoting proliferation and suppressing apoptosis, inflammation, and ECM degradation through a circ_0022383/miR-3619-5p/SIRT1 ceRNA axis. |
| Confidence score: |
0.8275 |