circRNA basic information
circBase ID: -
Name: hsa_circ_CDYL
Synonym: circCDYL / Circular RNA CDYL
Host Gene: CDYL
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021063
MONDO name: malignant colon neoplasm
Disease details: colon cancer
Disease DO ID:
 219
Disease MeSH ID:
 -
Disease NCIt ID:
 C9242
Disease ICD11 ID:
 1265576634
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

colon cancer tissues; paired surrounding normal tissues
Cell lines:

SW480; SW620
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTEN, PI3K, AKT, JAK2, STAT5, c-Myc, cyclin D1, p53, caspase-3, PARP
Associated microRNA: miR-150-5p
Biological function: circCDYL suppresses colon cancer cell viability, colony formation, migration and invasion, and promotes apoptosis.
Molecular mechanism: circCDYL represses miR-150-5p, increases PTEN, and blocks PI3K/AKT and JAK/STAT signaling cascades to exert an antitumor role in colon cancer cells.
Biological pathway or process:

PI3K/AKT (inhibits); JAK/STAT (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot
Clinical significance:

circCDYL is decreased in colon cancer tissues and was considered a promising candidate for colon cancers.
Description:

circCDYL was down-regulated in colon cancer tissues compared with adjacent tissues. Its overexpression inhibited colon cancer cell growth, migration and invasion, promoted apoptosis, and acted through repression of miR-150-5p with downstream blockade of PI3K/AKT and JAK/STAT signaling.
Confidence score:

0.5434
Other information
Title:

circCDYL/microRNA-105-5p participates in modulating growth and migration of colon cancer cells.

Journal: General physiology and biophysics
Published: 2019
PubMed ID: 31829306
Study type:

combined biological and clinical study
Data availability: -
Code availability: -