circRNA basic information
circBase ID: hsa_circ_0003247
Name: hsa_circ_ASH1L
Synonym: circASH1L / circASH1L-1
Host Gene: ASH1L
Genomic location(hg19): chr1:155408117-155429689:-
Genomic location(hg38): chr1:155438326-155459898:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer / TNBC
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues
Cell lines:

MBA-MD-231
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PIK3R3, PI3K, p-PI3K, AKT, p-AKT, Ki67
Associated microRNA: -
Biological function: Promotes tumor growth and proliferation in TNBC.
Molecular mechanism: Modulates PI3K/AKT signaling pathway activity (altering levels of pathway marker proteins) in TNBC xenograft tumors.
Biological pathway or process:

PI3K/AKT (promotes); proliferation (promotes)
Detected method:
M
Validation methods:

Bioinformatics Analysis; Transfection; In Vivo Animal Model; IHC (Immunohistochemistry); Western Blot; Microarray
Clinical significance:

-
Description:

circASH1L (hsa_circ_0003247) is up-regulated in TNBC clinical samples (GSE113230) and promotes TNBC xenograft tumor growth. Manipulating circASH1L levels alters Ki67 proliferation and PI3K/AKT pathway marker proteins, supporting a tumor-promoting role via PI3K/AKT activation.
Confidence score:

0.5546
Other information
Title:

CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms.

Journal: Open medicine (Warsaw, Poland)
Published: 2025
PubMed ID: 40918151
Study type:

combined biological and clinical study
Data availability: GSE113230
Code availability: -