circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: -
Host Gene: HIPK3
Genomic location(hg19): chr11:33307959-33309057:.
Genomic location(hg38): chr11:33286413-33287511:.
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0000872
MONDO name: B-cell childhood acute lymphoblastic leukemia
Disease details: pediatric B-precursor acute lymphoblastic leukemia
Disease DO ID:
 0080146
Disease MeSH ID:
 -
Disease NCIt ID:
 C9140
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs)
Cell lines:

-
In vivo animal model:

patient-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-124
Biological function: could influence the growth of leukemic cells
Molecular mechanism: miRNA sponging (e.g., miR-124) inferred from prior studies; not experimentally validated in BCP-ALL in this paper.
Biological pathway or process:

proliferation (other); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; In Vivo Animal Model
Clinical significance:

-
Description:

circHIPK3 is upregulated in pediatric BCP-ALL (qRT-PCR in PDX samples). Prior evidence cited by the authors indicates it localizes to the cytoplasm and can sponge miRNAs (e.g., miR-124), suggesting a potential role in supporting leukemic cell growth, though this mechanism is not directly tested here.
Confidence score:

0.4128
Other information
Title:

Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia.

Journal: Scientific reports
Published: 2019
PubMed ID: 31605010
Study type:

combined biological and clinical study
Data availability: GSE110159
Code availability: -