| Expression pattern: |
UP |
| Associated gene: |
NF-kappaB, MMP2 |
| Associated microRNA: |
miR-615-5p, miR-6753-5p |
| Biological function: |
promotes cell proliferation, migration, and invasion; inhibits apoptosis; promotes tumor growth and peritoneal metastasis/peritoneal dissemination; induces mesothelial-to-mesenchymal transition (MMT) |
| Molecular mechanism: |
ceRNA sponging miR-615-5p and miR-6753-5p to upregulate NF-kappaB and MMP2; exosomal circPUM1 acts on peritoneal mesothelial cells to induce MMT and promote peritoneal dissemination |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); EMT (promotes); NF-kappaB (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circPUM1 expression was positively related with FIGO stage in ovarian cancer |
| Description: |
circPUM1 is upregulated in ovarian cancer tissues and promotes proliferation, migration, invasion and metastasis while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging miR-615-5p and miR-6753-5p to increase NF-kappaB and MMP2 expression, and it is also secreted via exosomes to act on peritoneal mesothelial cells, inducing MMT and enhancing peritoneal dissemination. |
| Confidence score: |
0.6544 |