circRNA basic information
circBase ID: hsa_circ_0004619
Name: hsa_circ_FAF1
Synonym: -
Host Gene: FAF1
Genomic location(hg19): chr1:51121113-51210447:-
Genomic location(hg38): chr1:50655441-50744775:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011385
MONDO name: intervertebral disk degenerative disorder
Disease details: human intervertebral disc degeneration / IDD
Disease DO ID:
 90
Disease MeSH ID:
 D055959
Disease NCIt ID:
 C26983
Disease ICD11 ID:
 -
Disease OMIM ID:
 603932
Species: Human
Species details: Homo sapiens
Tissue specimen:

human lumbar NP specimens / degenerative human lumbar NP specimens / human intervertebral disc samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FAF1
Associated microRNA: -
Biological function: Potentially involved in IDD through inverse co-expression with FAF1, a Fas pathway gene.
Molecular mechanism: Host gene co-expression/inverse expression with FAF1; possible involvement in Fas pathway.
Biological pathway or process:

apoptosis (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

Potential use in diagnosis and clinical treatment of IDD in the future.
Description:

hsa_circ_0004619 was identified as downregulated in IDD while its host gene FAF1 was upregulated. The study links this circRNA-host gene pair to the Fas pathway, but the association was based on microarray and bioinformatic co-expression analysis rather than direct functional validation.
Confidence score:

0.1768
Other information
Title:

Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.

Journal: Molecular medicine reports
Published: 2017
PubMed ID: 28990083
Study type:

bioinformatics study
Data availability: GSE56081; GSE67566
Code availability: -