| Expression pattern: |
UP |
| Associated gene: |
XPO1, Ago2, p53 |
| Associated microRNA: |
miR-23a-3p, miR-23b-3p, miR-23c, miR-130a-5p |
| Biological function: |
Facilitates osteosarcoma cell growth, colony formation and invasion, and decreases apoptosis. |
| Molecular mechanism: |
Circ-XPO1 acts as a competing endogenous RNA that sponges miR-23a-3p, miR-23b-3p, miR-23c, and miR-130a-5p to upregulate XPO1 expression; circ-XPO1 inhibition retains nuclear p53 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); p53 signaling (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-XPO1 expression correlated with poor prognosis for patients with osteosarcoma. |
| Description: |
Circ-XPO1 is up-regulated in osteosarcoma tissues and cells and high expression predicts poor overall survival. It promotes OS cell viability, colony formation and invasion while inhibiting apoptosis, acting mainly as a cytoplasmic ceRNA that sponges miR-23a-3p, miR-23b-3p, miR-23c and miR-130a-5p to increase XPO1 expression. |
| Confidence score: |
0.8625 |