| Expression pattern: |
UP |
| Associated gene: |
SOX4 |
| Associated microRNA: |
miR-1225-3p |
| Biological function: |
promotes growth, migration and invasion of breast cancer cells |
| Molecular mechanism: |
circ_0000518 acts as a molecular sponge of miR-1225-3p to up-regulate SOX4 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
circ_0000518 expression was markedly associated with tumor size, lymph node metastasis, TNM stage and tumor differentiation |
| Description: |
circ_0000518 is up-regulated in breast cancer tissues and cell lines and promotes proliferation, migration, and invasion in vitro. It acts as a ceRNA by sponging miR-1225-3p, thereby relieving repression of SOX4 and enhancing SOX4 expression. |
| Confidence score: |
0.697 |