| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-1236-3p, hsa-miR-3064-5p, hsa-miR-6504-5p, hsa-miR-943, hsa-miR-522-3p, hsa-miR-155-5p, hsa-miR-663a, hsa-miR-766-5p, hsa-miR-449b-3p, hsa-miR-494-5p |
| Biological function: |
Associated with increased lymphatic metastases in ESCC; may regulate invasion and metastasis of ESCC cells. |
| Molecular mechanism: |
Predicted circRNA/miRNA sponge mechanism through MREs; hsa_circRNA_100873 may downregulate hsa-miR-663a through direct binding, thereby regulating metastasis and invasion in ESCC cells. |
| Biological pathway or process: |
metastasis (promotes); invasion (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
May be associated with increased lymphatic metastases in ESCC and may be a potential novel target for diagnosis and treatment of ESCC. |
| Description: |
hsa_circRNA_100873 was identified by microarray and validated by RT-qPCR as upregulated in ESCC tissues, especially in the low-invasive high-lymphatic metastasis group. The study suggests that hsa_circRNA_100873 may promote ESCC lymphatic metastasis and invasion through a predicted miRNA-sponge mechanism, particularly involving hsa-miR-663a, and may have potential diagnostic or therapeutic value. |
| Confidence score: |
0.5135 |