| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential liquid biopsy biomarker for detecting GC and differentiating GC from controls/gastritis; higher levels associate with more aggressive clinicopathological features. |
| Molecular mechanism: |
Not specified; study focuses on diagnostic performance and stability/secretory characteristics rather than mechanistic targets. |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Bioinformatics Analysis; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Agarose Gel Electrophoresis |
| Clinical significance: |
Upregulated in serum of GC patients; discriminates GC from controls (AUC 0.909) and contributes to a diagnostic model (GC-DM). Elevated expression correlates with multiple clinicopathological parameters (e.g., lymph node metastasis, TNM stage). |
| Description: |
hsa_circ_0001185 is significantly up-regulated in the serum of gastric cancer patients (also elevated in gastritis vs healthy controls) and shows strong diagnostic performance (AUC 0.909). It is included with hsa_circ_0005265 in a multicenter logistic-regression diagnostic model (GC-DM) and its higher expression correlates with more aggressive clinicopathological features such as lymph node metastasis and advanced TNM stage. |
| Confidence score: |
0.7734 |