| Expression pattern: |
UP |
| Associated gene: |
KPNA4, Ago2 |
| Associated microRNA: |
miR-1298-5p |
| Biological function: |
promotes paclitaxel resistance and tumorigenesis; promotes proliferation, migration, and invasion; inhibits apoptosis |
| Molecular mechanism: |
ceRNA sponging of miR-1298-5p to positively regulate KPNA4 |
| Biological pathway or process: |
chemoresistance (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ_0000376 is up-regulated in paclitaxel-resistant NSCLC tissues and cells and promotes PTX resistance and malignant phenotypes. Mechanistically, it sponges miR-1298-5p to increase KPNA4 expression, enhancing tumor growth and reducing chemosensitivity in vitro and in xenograft models. |
| Confidence score: |
0.795 |