| Expression pattern: |
UP |
| Associated gene: |
MCL1 |
| Associated microRNA: |
miR-892b |
| Biological function: |
circEPSTI1 promotes osteosarcoma cell proliferation, migration, invasion, tumor growth and lung metastasis; knockdown of circEPSTI1 suppresses these malignant phenotypes. |
| Molecular mechanism: |
circEPSTI1 acts as a ceRNA and miRNA sponge for miR-892b to regulate MCL1 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; Bioinformatics Analysis |
| Clinical significance: |
circEPSTI1 may serve as a target and biomarker for osteosarcoma treatment. |
| Description: |
circEPSTI1 is upregulated in osteosarcoma and promotes malignant progression, including proliferation, migration, invasion, tumor growth and lung metastasis. Mechanistically, circEPSTI1 functions as a ceRNA by sponging miR-892b to regulate MCL1 expression, suggesting potential value as a therapeutic target and biomarker. |
| Confidence score: |
0.7302 |