circRNA basic information
circBase ID: -
Name: -
Synonym: circ_001569
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissue samples; corresponding non-tumorous tissues; paired normal liver tissues
Cell lines:

L02; HepG2; Huh7; SMMC7721; Sk-Hep-1; HCCLM3
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-411-5p, miR-432-5p
Biological function: circ_001569 promotes HCC cell growth, migration, invasion, tumor formation and lung metastasis.
Molecular mechanism: circ_001569 functions as a miRNA sponge for miR-411-5p and miR-432-5p, and its oncogenic functions are partially dependent on regulating miR-411-5p and miR-432-5p expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Luciferase Reporter Assay; Bioinformatics Analysis; Cohort Study; Survival Analysis
Clinical significance:

High circ_001569 expression is correlated with larger tumor size, advanced TNM stages and poor prognosis, and circ_001569 was identified as an independent prognostic predictor for HCC patients.
Description:

circ_001569 is up-regulated in HCC tissues and cell lines, and its high expression is associated with larger tumor size, advanced TNM stage and poor postoperative prognosis. Functionally, it promotes HCC cell growth, migration, invasion, tumor formation and lung metastasis. Mechanistically, circ_001569 acts as a sponge for miR-411-5p and miR-432-5p, and its oncogenic activity is partially dependent on regulation of these miRNAs.
Confidence score:

0.7483
Other information
Title:

Overexpression of circular RNA circ_001569 indicates poor prognosis in hepatocellular carcinoma and promotes cell growth and metastasis by sponging miR-411-5p and miR-432-5p.

Journal: Biochemical and biophysical research communications
Published: 2018
PubMed ID: 30086881
Study type:

combined biological and clinical study
Data availability: -
Code availability: -