| Expression pattern: |
UP |
| Associated gene: |
SIRT1 |
| Associated microRNA: |
miR-217 |
| Biological function: |
hsa_circ_0000594 promotes HB cell proliferation, viability, migration/invasion and malignant phenotypes, and reduces apoptosis; knockdown inhibits malignant phenotype. |
| Molecular mechanism: |
hsa_circ_0000594 acts as a miR-217 sponge and regulates the miR-217 target gene SIRT1, forming the hsa_circ_0000594/miR-217/SIRT1 regulatory axis in HB. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other); metastasis (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
ISH (In Situ Hybridization); RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Western Blot |
| Clinical significance: |
hsa_circ_0000594 may serve as a novel diagnostic marker, prognostic biomarker, and potential therapeutic target for HB; its expression is associated with the subtype of HB. |
| Description: |
hsa_circ_0000594 is upregulated in hepatoblastoma tissues and may serve as a diagnostic/prognostic biomarker and therapeutic target. Functionally, it supports HB malignant phenotypes by promoting proliferation, viability, migration/invasion and reducing apoptosis. Mechanistically, it acts through a hsa_circ_0000594/miR-217/SIRT1 regulatory axis. |
| Confidence score: |
0.6829 |