circRNA basic information
circBase ID: -
Name: mmu_circ_FOXO3
Synonym: Circ-Foxo3 / CircFoxo3
Host Gene: FOXO3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

tumor mass; tumor tissue
Cell lines:

4T1; MDA-MB-231
In vivo animal model:

syngeneic model
circRNA-disease information
Expression pattern:
DN
Associated gene: Foxo3 protein, p53
Associated microRNA: -
Biological function: May enable breast cancer stem-like cells (spheroid-forming tumor cells) to evade apoptosis; associated with apoptotic resistance.
Molecular mechanism: Not experimentally defined in this study; authors suggest reduced circ-Foxo3 may contribute to apoptosis evasion in breast CSCs.
Biological pathway or process:

apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; In Vivo Animal Model; H&E Staining
Clinical significance:

-
Description:

circ-Foxo3 is significantly down-regulated in spheroid-forming breast tumor cells enriched for cancer stem-like cells, and the study suggests this reduction may contribute to apoptosis evasion/apoptotic resistance in breast CSCs.
Confidence score:

0.3957
Other information
Title:

Downregulation of circ-Foxo3 in breast cancer stem-like cells.

Journal: BMC research notes
Published: 2023
PubMed ID: 37400900
Study type:

biological research
Data availability: The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.
Code availability: -