| Expression pattern: |
UP |
| Associated gene: |
CDH2, CHD2, Ago2 |
| Associated microRNA: |
microRNA-144 |
| Biological function: |
promotes ovarian cancer progression, proliferation, and migration; potential diagnostic and therapeutic marker |
| Molecular mechanism: |
circUBAP2 acts as a ceRNA sponge for microRNA-144, negatively regulates microRNA-144 expression, and affects the microRNA-144/CDH2 pathway to promote proliferation and migration |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Western Blot; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
circUBAP2 effectively distinguished OC tissues from normal ovarian tissues; high circUBAP2 expression was associated with TNM/TMN stage and lower five-year survival rate |
| Description: |
circUBAP2 is up-regulated in ovarian cancer tissues and cell lines and is associated with advanced stage and poorer five-year survival. It mainly localizes to the cytoplasm and promotes OC cell proliferation and migration by sponging microRNA-144, thereby affecting the microRNA-144/CDH2 regulatory pathway. The study suggests circUBAP2 may serve as a diagnostic and therapeutic marker for OC. |
| Confidence score: |
0.7942 |