| Expression pattern: |
UP |
| Associated gene: |
MYH9 |
| Associated microRNA: |
miR-204-5p |
| Biological function: |
Promotes glycolysis, migration, invasion, and tumor growth in gastric cancer under hypoxia. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-204-5p, thereby regulating MYH9 expression (miR-204-5p/MYH9 axis). |
| Biological pathway or process: |
glycolysis (promotes); migration (promotes); invasion (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
High circSLAMF6 level is associated with shorter survival time in GC patients. |
| Description: |
circSLAMF6 is up-regulated in gastric cancer (including under hypoxia) and promotes glycolysis, migration, invasion, and tumor growth. Mechanistically, circSLAMF6 sponges miR-204-5p to increase MYH9 expression, forming the circSLAMF6/miR-204-5p/MYH9 axis. High circSLAMF6 expression is associated with shorter overall survival in GC patients. |
| Confidence score: |
0.7507 |