| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
microRNA-361-3p, miR-361-3p, mir-361-3p |
| Biological function: |
Promotes proliferation, invasion, migration, metastasis and malignant progression of breast cancer cells; knockdown inhibits proliferation, invasion and migration. |
| Molecular mechanism: |
circRNA_100876 acts as a miRNA sponge by adsorbing microRNA-361-3p and regulating its expression, thereby promoting proliferation, invasion and migration of breast cancer cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High expression of circRNA_100876 is associated with distant metastasis and poor prognosis in breast cancer patients. |
| Description: |
circRNA_100876 is up-regulated in breast cancer tissues and cell lines, with higher levels in patients with distant metastasis. High circRNA_100876 expression predicts poor prognosis, and functional experiments indicate that it promotes breast cancer cell proliferation, invasion, migration and metastasis. Mechanistically, circRNA_100876 acts as a sponge for microRNA-361-3p and regulates microRNA-361-3p expression. |
| Confidence score: |
0.7078 |