circRNA basic information
circBase ID: -
Name: hsa_circ_BACH1
Synonym: circ-BACH1
Host Gene: BACH1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005047
MONDO name: infertility disorder
Disease details: infertility
Disease DO ID:
 5223
Disease MeSH ID:
 D007246
Disease NCIt ID:
 C3836
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

endometrial samples
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: ATHL1, HTR6, KIAA1755, PLIN4, PRRT2, SNX29
Associated microRNA: 35 downregulated miRs
Biological function: circBACH1 may play a crucial/dominant role in the predicted regulatory network, may influence endometrial receptivity as a ceRNA of miRs, and may serve as a biomarker of endometrial receptivity.
Molecular mechanism: Predicted ceRNA mechanism involving circBACH1, downregulated miRs, and mRNAs including ATHL1, HTR6, KIAA1755, PLIN4, PRRT2, and SNX29.
Biological pathway or process:

ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

circBACH1 can serve as a biomarker of endometrial receptivity.
Description:

circBACH1 was significantly upregulated in endometrial samples from infertile patients receiving acupuncture and moxibustion. The study highlighted circBACH1 as the most connected circRNA in the predicted ceRNA network and proposed it as a potential biomarker and regulator of endometrial receptivity.
Confidence score:

0.4032
Other information
Title:

Circular RNA sequencing reveals the molecular mechanism of the effects of acupuncture and moxibustion on endometrial receptivity in patients undergoing infertility treatment.

Journal: Molecular medicine reports
Published: 2019
PubMed ID: 31257480
Study type:

combined clinical and bioinformatics study
Data availability: available from the corresponding author on reasonable request
Code availability: -