| Expression pattern: |
UP |
| Associated gene: |
TAF15, PTBP1 mRNA |
| Associated microRNA: |
- |
| Biological function: |
Promotes hepatoblastoma progression (proliferation, migration, invasion, EMT) and inhibits apoptosis; accelerates tumor growth in vivo. |
| Molecular mechanism: |
circ-CCT2 binds/recruits TAF15 in the cytoplasm, up-regulates TAF15 protein, and stabilizes PTBP1 mRNA, leading to activation of Wnt/beta-catenin signaling. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
High circ-CCT2 expression is associated with metastasis in hepatoblastoma patients; proposed as a potential therapeutic target. |
| Description: |
circ-CCT2 is up-regulated in hepatoblastoma and mainly localizes to the cytoplasm. It promotes malignant phenotypes and xenograft tumor growth by recruiting/up-regulating the RBP TAF15, thereby stabilizing PTBP1 mRNA and activating Wnt/beta-catenin signaling. |
| Confidence score: |
0.8232 |