| Expression pattern: |
UP |
| Associated gene: |
MAP3K9 |
| Associated microRNA: |
miR-1193 |
| Biological function: |
Promotes CSCC progression by enhancing proliferation, migration, invasion, and glycolysis and inhibiting apoptosis. |
| Molecular mechanism: |
Acts as a ceRNA/molecular sponge for miR-1193 to increase MAP3K9 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Patients with high circSEC24A level had shorter overall survival than those with low circSEC24A level. |
| Description: |
circSEC24A is up-regulated in CSCC tissues/cells and functions as an oncogenic circRNA. It sponges miR-1193 to de-repress MAP3K9, thereby promoting proliferation, migration/invasion and glycolysis while inhibiting apoptosis; silencing circSEC24A suppresses xenograft tumor growth and is associated with better overall survival in patients with low circSEC24A. |
| Confidence score: |
0.8324 |