circRNA basic information
circBase ID: hsa_circ_0014617
Name: -
Synonym: novel_circ_0014617
Host Gene: -
Genomic location(hg19): chr1:155695172-155706854:+
Genomic location(hg38): chr1:155725381-155737063:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005721
MONDO name: coxsackievirus infectious disease
Disease details: Coxsackievirus Group B5 infection
Disease DO ID:
 -
Disease MeSH ID:
 D003384
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

SH-SY5Y
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: DNAJB6, VPS4A
Associated microRNA: hsa-miR-29a-5p, hsa-miR-4535, hsa-miR-138-5p, hsa-miR-665
Biological function: inhibits CVB5 replication; promotes key factors in the IFN-I signaling pathway
Molecular mechanism: circRNA-miRNA-mRNA (ceRNA) network associated with innate immune response/IFN-I signaling; enriched in RIG-I signaling pathway network
Biological pathway or process:

other pathway/process (other); immune regulation (promotes); viral replication (inhibits); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Transfection; Western Blot
Clinical significance:

-
Description:

In CVB5-infected SH-SY5Y cells, novel_circ_0014617 (also reported as hsa_circ_0014617) is up-regulated and inhibits viral replication when overexpressed by promoting key factors in the IFN-I pathway. It is part of a predicted circRNA-miRNA-mRNA network linked to innate immune response, including a RIG-I signaling pathway-related subnetwork.
Confidence score:

0.4474
Other information
Title:

Expression Profiles of Differentially Expressed Circular RNAs and circRNA-miRNA-mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5.

Journal: International journal of genomics
Published: 2022
PubMed ID: 36267594
Study type:

biological research
Data availability: GEO180816
Code availability: -