| Expression pattern: |
UP |
| Associated gene: |
NTRK3 |
| Associated microRNA: |
microRNA-485-3p |
| Biological function: |
circ-100219 promotes the proliferative and migratory capacities of breast cancer cells; circ-100219 knockdown inhibits proliferation and migration. |
| Molecular mechanism: |
circ-100219 binds/sponges microRNA-485-3p and upregulates or stabilizes NTRK3 expression, thereby promoting breast cancer cell proliferation and migration. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot |
| Clinical significance: |
circ-100219 expression was significantly higher in advanced-stage breast cancer tissues and may possess diagnostic and therapeutic values on breast cancer. |
| Description: |
circ-100219 is up-regulated in breast cancer tissues and cell lines, with higher expression in advanced-stage tumors. Functionally, circ-100219 promotes breast cancer cell proliferation and migration by binding/sponging microRNA-485-3p and increasing NTRK3 expression. The study suggests circ-100219 may have diagnostic and therapeutic relevance in breast cancer. |
| Confidence score: |
0.6479 |