| Expression pattern: |
UP |
| Associated gene: |
YBX1 |
| Associated microRNA: |
miR-375 |
| Biological function: |
Promotes gastric cancer cell proliferation and invasion; hsa_circ_0008035 knockdown represses proliferation and metastasis of gastric cancer cells. |
| Molecular mechanism: |
hsa_circ_0008035 acts as a miR-375 sponge and regulates the miR-375/YBX1 axis. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0008035 is significantly overexpressed in clinical gastric cancer tissue. |
| Description: |
hsa_circ_0008035 is an up-regulated circRNA in gastric cancer tissues and cells. It promotes gastric cancer cell proliferation, invasion and metastasis-related phenotypes by functioning as a miR-375 sponge and regulating the miR-375/YBX1 axis. |
| Confidence score: |
0.6815 |