| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
circ_0005075 acts as an oncogene in CRC; it enhances CRC cell proliferation, migration, invasion, EMT and tumor progression, while inhibiting apoptosis. |
| Molecular mechanism: |
circ_0005075 displays tumor-promotive roles by activating the Wnt/beta-catenin signaling pathway and promoting EMT-associated changes. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Cohort Study; Survival Analysis |
| Clinical significance: |
High circ_0005075 expression is associated with histology/differentiation, depth of invasion, advanced TNM stage, shorter overall survival and disease-free survival; it may serve as a prognostic biomarker and therapeutic target for CRC patients. |
| Description: |
hsa_circ_0005075/circ_0005075 is up-regulated in colorectal cancer tissues and cell lines and its high expression predicts poorer overall and disease-free survival. Functionally, circ_0005075 promotes CRC cell proliferation, migration, invasion, EMT and metastasis while suppressing apoptosis. Mechanistically, the study supports an oncogenic role through activation of the Wnt/beta-catenin pathway. |
| Confidence score: |
0.6589 |