| Expression pattern: |
UP |
| Associated gene: |
Sp1 |
| Associated microRNA: |
microRNA-150-5p |
| Biological function: |
Promotes proliferation, migration, invasion, growth and metastatic ability of NPC cells. |
| Molecular mechanism: |
circ-ZNF609 acts as a ceRNA by binding microRNA-150-5p, inhibiting microRNA-150-5p expression and indirectly upregulating/stabilizing Sp1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot |
| Clinical significance: |
circ-ZNF609 may serve as a diagnostic hallmark and therapeutic target for NPC. |
| Description: |
circ-ZNF609 is up-regulated in nasopharyngeal carcinoma tissues and cell lines. It promotes NPC cell proliferation, migration, invasion and metastatic ability by acting as a ceRNA that binds microRNA-150-5p and upregulates Sp1. The study suggests circ-ZNF609 may be a diagnostic hallmark and therapeutic target for NPC. |
| Confidence score: |
0.7404 |