circRNA basic information
circBase ID: -
Name: -
Synonym: circRNA-100438
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MDA-MB-231; MCF-7; MDA-MB-453; SKBR-3; T47D; MDA-MB-468; MCF-7R; MDA-MB-231R
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Silencing of circRNA-100438 had no significant effect on breast cancer cell viability, and it demonstrated no effect on monastrol resistance.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR
Clinical significance:

-
Description:

circRNA-100438 was identified by microarray and RT-qPCR as dysregulated between monastrol-resistant and parental breast cancer cells. Unlike circRNA-MTO1, preliminary silencing experiments suggested no significant effect on breast cancer cell viability or monastrol resistance, and its role remains unclear.
Confidence score:

0.1904
Other information
Title:

Circular RNA‑MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis.

Journal: International journal of oncology
Published: 2018
PubMed ID: 30015883
Study type:

biological research
Data availability: The analyzed data sets generated during the study are available from the corresponding author on reasonable request.
Code availability: -