| Expression pattern: |
UP |
| Associated gene: |
MMP13 |
| Associated microRNA: |
miR-136 |
| Biological function: |
circRNA-CER promotes breast cancer cell proliferation and migration; knockdown of circRNA-CER suppresses proliferation and migration of MCF-7 cells. |
| Molecular mechanism: |
circRNA-CER functions as a competing endogenous RNA and sponge for miR-136, thereby regulating MMP13 expression through the miR-136/MMP13 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Western Blot; IHC (Immunohistochemistry) |
| Clinical significance: |
circRNA-CER may be a potential biomarker and molecular target for prediction, diagnosis and treatment of breast cancer. |
| Description: |
circRNA-CER is upregulated in breast cancer tissues and promotes malignant phenotypes in breast cancer cells. Mechanistically, circRNA-CER acts as a miR-136 sponge to regulate MMP13 expression, thereby supporting MCF-7 cell proliferation and migration. The study proposes circRNA-CER as a potential biomarker or molecular target for breast cancer prediction, diagnosis and treatment. |
| Confidence score: |
0.6148 |