circRNA basic information
circBase ID: hsa_circ_0003615
Name: hsa_circ_ALG8
Synonym: circALG8
Host Gene: ALG8
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent non-tumor tissues; plasma samples
Cell lines:

NCI-H1299; A549
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May serve as a stable, noninvasive plasma biomarker and part of a diagnostic panel for early-stage NSCLC.
Molecular mechanism: circALG8 is generated by back-splicing of ALG8 exons 9 to 11 and exhibits RNase R resistance and longer half-life than ALG8 mRNA, supporting structural stability as a circular RNA biomarker.
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; circRNA-seq; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Downregulated circALG8 is significantly associated with TNM staging and may serve as a diagnostic biomarker for early-stage NSCLC, especially in combination with circCAMTA1 and traditional tumor markers.
Description:

circALG8 is a human ALG8-derived circular RNA that is downregulated in NSCLC tumor tissues and plasma. The study validates its circular stability and supports its use as a noninvasive diagnostic biomarker, particularly as part of a plasma circALG8/circCAMTA1 panel for early-stage NSCLC.
Confidence score:

0.6676
Other information
Title:

Plasma-derived circALG8 and circCAMTA1 as a panel for early diagnosis of non-small cell lung cancer.

Journal: Biomarkers in medicine
Published: 2025
PubMed ID: 40754803
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -